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Pneumonia (Paediatric, Recurrent or Persistent)

Population Covered By The Guidance

This pathway provides guidance on the imaging of paediatric patients with recurrent pneumonia

Lead Researcher: Arjun Shivananda

Experts & Contributors: Ravinder Dhillon, Michael Ditchfield, Peter Shipman

Date reviewed: July 2017

Date Published: September 2017

Image 1a and 1b (Computed Tomography): Mild bilateral bronchiectasis predominantly involving the lower lobes. There are multiples areas of

Cystic Fibrosis with Bronchiectasis

Image 1a and 1b (Computed Tomography): Mild bilateral bronchiectasis predominantly involving the lower lobes. There are multiples areas of

Cystic Fibrosis with Bronchiectasis

Image 2a: Pneumonectomy showing grossly dilated bronchi with mucous plugging (blue arrows) and distal consolidation.

Cystic Fibrosis with Bronchiectasis

Image 2b (H&E, x2.5): Section of a dilated bronchi with florid acute on chronic inflammation of the bronchial wall and surrounding interstitial

Cystic Fibrosis with Bronchiectasis

  • Recurrent pneumonia - two episodes within the same year, or 3 or more episodes over any time period. For a child to be diagnosed with recurrent pneumonia, there must be complete resolution of clinical and radiological findings between acute episodes
  • Persistent or non-resolving pneumonia - when there is clinical and radiological evidence of pneumonia despite adequate treatment for a month
  • Plain chest x-ray is indicated initially, with comparison to previous films essential
  • Further investigations are dictated by the most likely diagnosis, based on the age of the child, the onset of symptoms and findings on clinical history and examination. CT of the chest or bronchoscopy may be indicated

References are graded from Level I to V according to the Oxford Centre for Evidence-Based Medicine, Levels of Evidence. Download the document

  1. Vaughan D, Katkin JP. Chronic and recurrent pneumonias in children. Semin Respir Infect. 2002;17(1):72-84. (Review article). View the reference
  2. Montella S, Corcione A, Santamaria F. Recurrent Pneumonia in Children: A Reasoned Diagnostic Approach and a Single Centre Experience. Int J Mol Sci. 2017;18(2):296. (Review article). View the reference
  3. Wald ER. Recurrent and nonresolving pneumonia in children. Semin Respir Infect. 1993;8(1):46-58. (Review article). View the reference
  4. Yousif TI, Elnazir B. Approach to a child with recurrent pneumonia. Sudanese Journal of Paediatrics. 2015;15(2):71-7. (Review article). View the reference
  5. Gaston B. Pneumonia. Pediatr Rev. 2002;23(4):132-40. (Review article). View the reference
  6. Donnelly LF, Klosterman LA. The yield of CT of children who have complicated pneumonia and noncontributory chest radiography AJR Am J Roentgenol. 1998;170(6):1627-31. (Level III evidence). View the reference
  7. Liu YL, Wu PS, Tsai LP, Tsai WH. Pediatric round pneumonia. Pediatr Neonatol. 2014;55(6):491-4. (Level IV evidence). View the reference
  8. Copley SJ. Application of computed tomography in childhood respiratory infections. Br Med Bull. 2002;61:263-79. (Review article). View the reference
  9. Bayramoglu S, Cimilli T, Aksoy S, Yildiz S, Salihoglu B, Hatipoglu S, et al. The role of HRCT versus CXR in children with recurrent pulmonary infections. Clin Imaging. 2005;29(5):317-24. (Level III evidence). View the reference
  10. Rosbe KW, Kenna MA, Auerbach AD. Extraesophageal reflux in pediatric patients with upper respiratory symptoms. Arch Otolaryngol Head Neck Surg. 2003;129(11):1213-20. (Level III evidence). View the reference
  11. Yellon RF, Goldberg H. Update on gastroesophageal reflux disease in pediatric airway disorders. Am J Med. 2001;111 Suppl 8A:78-84. (Review article). View the reference

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Status Of Recommendations Each pathway is designed to assist clinicians in situations when faced with a large array of possible diagnostic tests and examinations. However, it is recognised that diagnostic practice may differ from a particular pathway depending on local availability of equipment and expertise, as well as the experience of individual clinicians. Therefore each pathway is neither a rigid set of rules, nor a substitute for clinical assessment, and individual patient circumstances should always be considered.

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Date reviewed: July 2017Please note that this pathway issubject to review and revisionReview previousfilmsDiagnosisAppropriatetreatmentSuspectedchronic aspirationBronchial wallthickeningTest forasthmaSuspectedbronchiectasisSuspectedtracheobronchialstructural abnormalityor vascular ring/slingExclude immunologicaldisorders and cystic fibrosisPlain Radiography(CXR)Single lobeinvolvementMultiple lobeinvolvementUpper GI contraststudiesHRCTCT orBronchoscopyстor Bronchoscopyor Upper GIcontrast studiesPERSISTENT ORRECURRENT PNEUMONIA

Recurrent or Persistent Pneumonia in Children

Recurrent or Persistent Pneumonia in Children

Universally agreed definitions do not exist for recurrent or persistent pneumonia

  • Pneumonia is clinically defined as a combination of respiratory symptoms (cough, dyspnoea, or tachypnoea) and signs (fever, crepitations, focally-reduced breath sounds, fremitus, or wheeze)
  • Unfortunately, there are no guidelines, or universal agreement for the definitions of recurrent and persistent pneumonia
  • Suggested definitions include
    • Recurrent pneumonia - two episodes within the same year, or three or more episodes over any time period. For a child to be diagnosed with recurrent pneumonia, there must be complete resolution of clinical and radiological findings between acute episodes
    • Persistent or non-resolving pneumonia - when there is clinical and radiological evidence of pneumonia despite adequate treatment for a month

Plain Radiography (CXR)

Plain Radiography (CXR)

Comparison to previous chest films should be made to assess whether the disease is recurrent or long standing

  • Not all children with pneumonia receive chest radiographs, but a radiograph demonstrating pulmonary infiltrates is essential in defining an episode of pneumonia in cases of suspected persistent or recurrent pneumonia
  • Comparison should be made to previous films to confirm the diagnosis of pneumonia and assess if the consolidation is recurrent or longstanding
  • Unlike adults, there is no indication for routine follow-up of all otherwise healthy children with uncomplicated community acquired pneumonia. Those with clinical evidence or suspicion of recurrent or persistent pneumonia, or who are immunocompromised should have repeat films done at least 2-3 weeks after commencement of treatment
  • Round pneumonia is common in children and simulates a pulmonary mass. In these cases, follow-up radiography is important to confirm resolution and to exclude the presence of an underlying mass

Computed Tomography (CT) and High Resolution Computed Tomography (HRCT)

Computed Tomography (CT)

Indications include

  • Suspected complications of bacterial pneumonia
  • Exclude an underlying abnormality in recurrent or persistent pneumonia
  • Investigating the immunocompromised child with a normal or equivocal radiograph
  • Evaluating children with suspected anomalies of the great vessels

  • The indications for CT in children with lower respiratory tract infections include
    • Suspected complications of bacterial pneumonia (e.g. abscess)
    • Exclude
    • Investigate the immunocompromised child with a normal or equivocal radiograph
  • CT is the preferred method for investigating neck or mediastinal compressive masses affecting the airway
  • CT results in significant exposure to ionising radiation and care must be taken to minimise the effective dose
  • High Resolution Computed Tomography (HRCT) is used for evaluating all forms of bronchiectasis (including cystic fibrosis) and interstitial lung diseases in children
  • HRCT should ideally be performed once acute infection has resolved in order to avoid issues with interpretation

Contrast Upper Gastrointestinal Studies

Contrast Upper Gastrointestinal Studies

May be useful in assessment of a child with associated gastroesophageal reflux or feeding difficulties

  • Indicated if aspiration, reflux, or mediastinal compressive masses/vascular rings compromising the airway are suspected

Single Lobe Involvement

Causes of Recurrent or Persistent Pneumonia Affecting a Single Lobe

  • Intraluminal obstruction: foreign body 
  • Extraluminal obstruction: infectious lymphadenopathy (TB, histoplasmosis, coccidiodiomycosis), non-infectious lymphadenopathy (sarcoidosis), tumour or congenital anomaly of the great vessels 
  • Structural abnormalities: bronchial stenosis/atresia, bronchiectasis, bronchogenic cyst or a sequestered lobe

Multiple Lobes Involvement

Causes of Recurrent or Persistent Pneumonia Affecting Multiple Lobes

  • Aspiration
  • Oesophageal obstruction / dysmotility: vascular ring, oesophageal web/stricture, achalasia, tracheoesophageal fistula or gastrointestinal reflux
  • Immunodeficiency syndromes: antibody deficiency/dysfunction, phagocytic disorder or complement deficiency
  • Mucocillary dysfunction: cystic fibrosis, primary ciliary dyskinesia
  • Miscellaneous: congenital heart disease, great vessel anomaly, asthma, alpha-1 antitrypsin deficiency, hypersensitivity pneumonitis

Computed Tomography (CT) and High Resolution Computed Tomography (HRCT)

High Resolution Computed Tomography (HRCT)

Imaging investigation of choice for diagnosing and identifying the type and extent of bronchiectasis

  • The indications for CT in children with lower respiratory tract infections include
    • Suspected complications of bacterial pneumonia (e.g. abscess)
    • Exclude
    • Investigate the immunocompromised child with a normal or equivocal radiograph
  • CT is the preferred method for investigating neck or mediastinal compressive masses affecting the airway
  • CT results in significant exposure to ionising radiation and care must be taken to minimise the effective dose
  • High Resolution Computed Tomography (HRCT) is used for evaluating all forms of bronchiectasis (including cystic fibrosis) and interstitial lung diseases in children
  • HRCT should ideally be performed once acute infection has resolved in order to avoid issues with interpretation

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